[email protected] conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. [email protected] was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Scientist in the Discovery Technologies, Organoid Group, will be joining a large and dynamic group focused on executing experiments on the cutting edge of pharmaceutical sciences. The candidate will execute experiments to support various research programs for identified targets and will be expected to demonstrate expertise with various organoid and patient-derived models, to be able to troubleshoot technical difficulties encountered in organoid growth, and to interrogate the work of third parties and collaborators. The candidate will also be encouraged to develop their own ideas, contribute these to the broader organoid group as well as project teams, and is expected to be a dynamic and motivated scientist who can drive their own experiments and research activities, while collaborating extensively with the rest of the organization to execute on various research programs. The candidate will collaborate with project teams in NYC, Indianapolis, SSF, and Boulder for design and execution of studies, and will work closely with multi-disciplinary teams, providing expertise throughout all stages of the lifecycle of target modulation and validation to advance our portfolio.

Roles and Responsibilities of the Position:

• Scientific roles and responsibilities:
• Develop key capabilities for the generation of necessary patient-derived organoid models for detailed functional characterization
• Design and execute studies to profile candidate molecules in organoid systems
• Troubleshoot technical difficulties encountered in organoid establishment, growth and testing
• Test biologics or small molecules in organoid tumor models (dose response experiments, profiling, comparing to control compounds)
• Grow organoids of various types; have extensive knowledge of media and growth factors on organoid development
• Perform experiments that modulate target expression in organoid systems
• Interrogate experimental conduct of third parties/vendors
• Additional responsibilities:
• Communicate results at project team meetings, be involved in the coordination and preparation of presentations
• Discuss results with technical as well as non-technical personnel
• Lead, and work collaboratively across multiple laboratory-based functions to establish the mechanisms, phenotypes, and biology of new targets using modern approaches in molecular and cellular biology and biochemistry
• Work in cross functional environments via extensive collaboration with other parts of the organization
• Direct leadership of a junior scientist may be required

Required Qualifications and Preferred Background:

• BS degree in biological sciences with 5 years of experience or MS/PhD in biological sciences with 2-3 years of experience required
• Extensive expertise working with organoid models
• Deep expertise in cancer disease states (indications, mutational status, tumor cell drivers)
• Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business
• Excellent communication and interpersonal skills
• Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
• Excellent written and verbal communication skills

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the {insert position} level position could range from between $78,000 to $ $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.

Physical Demands/ Travel:

The physical demands of this job are consistent with laboratory setting.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a lab.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email [email protected] for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.